Enhancement of gastric carcinogenesis in dogs given N-methyl-N'-nitro-N-nitrosoguanidine following vagotomy.
نویسندگان
چکیده
In an attempt to improve the method of induction of gastric cancer in dogs, selective vagotomy without drainage procedure was performed before administration of Nmethyl-N †̃-nitmo-N-nitrosoguanidine(MNNG). Twenty dogs were divided into two groups of 10 dogs (five beagles and five mongrels). The control group received MNNG alone. Dogs of the experimental group were vagotomized 2 months before administration of MNNG. MNNG solution (50 p.g/ml) was administered in the drinking water for i2 months. In the vagotomized group, gastric adenocarcino mas were induced in all of eight effective cases, whereas in the control group they were seen in six of eight cases. Gastric cancer was found to be multiple in many dogs, but the majority of cancer lesions remained in the early stage. The total numbers of cancer lesions induced in the vagot omy and control group were 42 and 16, respectively. Vagot omy resulted in the production of more advanced cancers. One lesion in the control group and four lesions in the vagotomy group were advanced cancer invading the se rosa. Advanced gastric cancers with metastases to the liver, lymph nodes, and lungs developed exclusively in two va gotomized dogs. Gastric acid secretion of the vagotomized dogs measured after termination of MNNG was reduced, on the average, to one-fourth of that of the control. The possible moleof vagotomy in the enhancement of gastric carcinogenesis in dogs by MNNG is discussed in terms of the inactivation of MNNG in gastric juice and ulcerogenic action of the carcinogen to the gastric mucosa.
منابع مشابه
Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens.
Helicobacter pylori (Hp) is thought to be a stomach carcinogen from epidemiological findings. To determine the effects of infection with the bacteria on experimental carcinogenesis, a study of the glandular stomach of Mongolian gerbils (MGs) was performed. Male MGs were treated with N-methyl-N'-nitro-N-nitrosoguanidine followed by inoculation with Hp or infected with Hp followed by N-methyl-N'-...
متن کاملEffect of calcium on rat gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine.
The effect of calcium carbonate (CaCO3) on the initiation of gastroduodenal carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was examined under the conditions with and without sodium chloride. Male Wistar rats were given drinking water containing MNNG (100 mg/liter) and one of the following diets during the first 20 weeks ad libitum. Group 1 was given basal diet; group 2, d...
متن کاملNaringenin Inhibits Oxidative Stress Induced Macromolecular Damage in N-methyl N-nitro N-nitrosoguanidine Induced Gastric Carcinogenesis in Wistar Rats
متن کامل
Effect of selective and non-selective muscarinic blockade on baclofen inhibition of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
The effects of baclofen, a gamma-amino-n-butyric acid receptor B agonist, on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine and how its effects are influenced by selective (M1) and non-selective (M1 and M2) pharmacological blockade of muscarinic receptors were investigated in inbred Wistar rats. Rats were given s.c. injections of 8 mg/kg body wt baclofen with and without...
متن کاملEndoscopic observation of N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rat using a newly-developed flexible endoscope.
Endoscopy can be used for sequential observation of gastric carcinogenesis in animal models. In the present study, we applied endoscopic examination and biopsy technique on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced stomach cancer in rats using a newly-developed flexible 2.5 mm endoscope. A total of 36 rats were divided into MNNG-treated and non-treated groups, observed on gastric endo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cancer research
دوره 39 3 شماره
صفحات -
تاریخ انتشار 1979